It is proved that in the knowledge economy, such assets of the company, like knowledge, are of particular value. New knowledge can increase the individual income of the owners as they apply in business processes and production activities. Defined knowledge management as the process of formation of the intellectual assets of the enterprise. Selected technological, motivational and organizational components of the system of knowledge management. The system methodology of knowledge management are methods to transform individual pieces of information in knowledge relating to a particular sphere of activity. System design of knowledge management of the enterprise is divided into a number of stages, which are discussed in the article. The analysis of world experience of the practical implementation of knowledge management has shown that organizations and businesses take this purpose a variety of techniques and methods. Found out that currently there are three schools of knowledge management. The methodology for the integration of knowledge in the enterprise, which is presented in the form of a diagram. The knowledge creation enterprise is carried out ways: through self-education personnel; by performing duties; tools of knowledge management. Proposed projects for the knowledge management implement in stages and characteristics of each stage. It is proved that the culture of designing the system of knowledge management should include management strategies, planning and provide for close cooperation and distribution of powers. It is concluded that knowledge management helps businesses become more competitive, reduce costs, increase the speed of making management decisions and efficiently identify the needs of consumers. The main purpose of the system of knowledge management of the enterprise is knowledge management an integral part of the work of all employees.