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Author: Assen Shulev

  • MATHEMATICAL MODELLING OF MEDICAL-BIOLOGICAL PROCESSES AND SYSTEMS

    Modelling, Simulation, and Prototyping of Hollow Microfluidic Channel for Investigation of Blood Cells

    • Tihomir Tiankov
    • Anika Alexandrova
    • Dimitar Trifonov
    • Emilia Abadjieva
    • Assen Shulev
    Mathematical Modeling, Vol. 7 (2023), Issue 3, pg(s) 94-97
    • Abstract
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    •  Article PDF

    The current publication presents an approach for the elaboration of a disposable microfluidic hollow micro-channel using 2 photon polymerization technology and Photonic Professional GT2 (Nanoscribe, Germany) equipment. The design of a 3D model of a microchannel is realized by the CAD analysis software – SOLIDWORKS. A suitable laminar flow is generated by using computational fluid dynamics (CFD) software. As a result, the critical points of the pressure, velocity, and wall shear stress into the microfluidic channel are obtained. A real prototype of the hollow microfluidic device is created, using a highly innovative technology of 3D nanoprinting by twophoton polymerization. Experimental studies with dilute erythrocyte suspensions are conducted to test the functionality of the developed prototype of nano 3D printed microchannel.

  • TECHNOLOGIES

    3D Design and Prototyping of a Microfluidic Device for Blood Cells’ Investigations

    • Tihomir Tiankov
    • Anika Alexandrova
    • Dimitar Trifonov
    • Emilia Abadjieva
    • Assen Shulev
    Machines. Technologies. Materials., Vol. 17 (2023), Issue 5, pg(s) 194-197
    • Abstract
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    •  Article PDF

    The present study offers an important technological approach for the development of a disposable microfluidic channel using 3D nanoprinter – Photonic Professional GT2 (Nanoscribe, Germany). This publication aims to present 3D modelling, simulation, and prototype of a 3D nanoprinted microfluidic device for the investigation of blood cells. The design of 3D model of a microchannel is realized by the 3D CAD analysis software – SOLIDWORKS. A suitable laminar flow is generated by using computational fluid dynamics (CFD) software. As a result, the critical points of the pressure, velocity and wall shear stress into the microfluidic channel are obtained. An actual physical prototype of the proposed microfluidic device is developed, using a highly innovative technology of 3D nanoprinting by two-photon polymerization. Experimental studies with dilute erythrocyte suspensions are conducted to test the functionality of the developed real-world prototype of nano 3D printed microchannel.

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