The main objective of the presented research is to improve and upgrade the existing methodologies for design and layout of test machines and equipment. The authors’ team has a significant experience in creating new test machines in the area of Machine Science, Machine elements, Automation and Measuring. The application of CAD systems within this research process of multivariate design is an additional advantage for the evaluation and analysis of different layout versions for the elaborated new test machines. The priority of combining electronic and mechanical measuring options is pointed out. The improved methodology is applied within the design process of a test machine for the experimental research of cardan drives.