The relevant task of animal husbandry is to provide animals with high-quality and cheap feed protein. In this regard, a promising direction is the use of a protein feed additive, produced as a result of the microbiological synthesis of the yeast Debaryomyces hansenii var hansenii (D.f.v.) during the processing of milk whey. To assess the results of the applicability of this additive when feeding animals, comparative tests were carried out with chicken replacements. It was found that the introduction of domestic protein feed additive in the compound feed of chicken replacements, produced by processing milk whey, equal to the amount of fish meal (5%) according to energy and protein nutrition, contributes to an increase in the growth rate of young chickens by 5.2%; reduction of feed costs per 1 kg increase in body weight by 4.5%; a more active evidence of physiological maturation of young chickens (by changing the first-order flight feathers); and an evidence of sexual dimorphism (by the size of the caruncle) in comparison with the control group.