The priorities of the simplified taxation system implementation in European countries aimed at the entrepreneurial incentives development, innovation introduction, and formation and strengthening of the SMEs competitiveness and economic growth have been studied. It has been found out that empirical findings show that high taxation rates potentially negatively affect entrepreneurial environment and high tax burden has sufficient adverse impact on SMEs business environment. Instruments of business support by the state both in the EU countries and in Ukraine have been determined. The main risks of the simplified taxation system for local budgets and entrepreneurial structures have been stated. The further fiscal system reforms aimed at SMEs motivation have been suggested.