Engineered nanomaterials based on graphene oxide and their potentials for combined cancer therapies

  • 1 Bulgarian Academy of Science, Institute of Biophysics and Biomedical Engeneering, Sofia, Bulgaria
  • 2 Bulgarian Academy of Science, Institute of Biophysics and Biomedical Engeneering, Sofia, Bulgaria; Bulgarian Academy of Science, Institute of Plant Physiology and Genetics, Sofia, Bulgaria


Graphene oxide, owing to its unique physicochemical properties, has established itself as a versatile platform with applications ranging from drug delivery to medical imaging. The modification of graphene oxide has the potential to enhance crucial properties such as near-infrared (NIR) adsorption capacity, water dispersity, and cytotoxicity. This paper aims to discuss the potential of unmodified graphene oxide and polyethylene glycol (PEG)-modified graphene oxide nanoparticles as responsive systems to NIR in the context of combined photothermal and chemotherapy. The focus is on their application for treating colorectal and hepatocellular cancer cells, highlighting their promise in integrated cancer therapies.



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