The work contains the main results of the development of a non-invasive method for the early diagnosis of skin pigmented lesions. The risk factors for the development of melanoma, their influence on the formation, development and degeneration of benign pigmented lesions in malignant ones are considered. Noninvasive methods for early diagnosis of pigmented skin lesions, their advantages and disadvantages, and informative indicators of diagnostic methods for early detection of lesions have been analysed. Diagnostic signs for the development of an automated noninvasive method for the early diagnosis of pigmented skin lesions have been formulated. And also formulated technical requirements for an automated complex for express diagnosis of pigmented skin lesions.