International Scientific Journals
of Scientific Technical Union of Mechanical Engineering "Industry 4.0"

Composite materials with potential application in medical textiles were developed by modifying cotton fabric with chitosan containing diclofenac. The influence of the concentration of citric acid as a crosslinking agent on the properties of the materials was studied. The resulting composite materials were characterized by gravimetric analysis, optical microscopy, contact angle measurement and thermogravimetric analysis. The antimicrobial activity of the cotton samples was evaluated against Gram-positive and Gram-negative model bacterial strains. A synergistic antimicrobial effect of chitosan and diclofenac and a uniform release of diclofenac in vitro under physiological conditions were established.