The open innovation is a concept of growing acceptance in the field of innovation management. It is based on the idea that companies can leverage the knowledge generated externally to improve their innovation performance. Open innovation as a process can promote shorter innovation cycles, increase in industrial research, and better optimization of the resources. However the process of open integration is much harder for implementations in SMEs than larger enterprises. The reasons behind the low integration of the open innovation as a process can be seen in the low capacity of the SMEs to deal with the open innovation process, low awareness of the benefits of the open innovation process, lack of knowledge for the intellectual law and rights, etc. This paper is based on the empirical research on 63 SMEs, in order to determine the factors (reasons) for low implementation of the open innovation process in the SMEs in Republic of Macedonia.