Abstract

An approach for creation of biophysically based models for the steady state current of cyclic processes is investigated. When the process (like chemical reactions) can be described by a system of linear ordinary differential equations, an analytic expression for its steady state exists. The analytic expression is especially simple for the current of single cycle processes. In biologic context, concentrations of many substances change in a very restricted (patho)physiological range. This allows neglecting some terms of the analytic expression and thus obtaining biophysically based models that are both simple and adequate for description of currents produced by enzymes, pumps or transporters. The approximations obtained could be reduced to the existing empirical models. A clear way of expanding a specific empirical model for obtaining the desired quality and range of validity is also represented. The described approach is general and can be useful for creating biophysically based models of other types of processes.