In this study, the effects of matrix structure (pearlitic, tempered martensitic, lower ausferritic, and upper ausferritic), boronizing temperature (800, 825, and 850°C) and time (3, 4.5 and 6 hours) on the wear behaviour of Cu-Ni-Mo alloyed ductile iron were investigated. Wear tests were performed on ball-on-disc type wear tester under the load of 6.8 N, at sliding speed of 6.5 mm/s, at room temperature and dry sliding conditions. The mass losses were measured after wear tests and the friction coefficients were obtained during wear tests. The hardnesses and thicknesses of boride layers, microstructures and worn surface examinations (SEM) of the matrix structures and borided layers were performed. The surface hardnesses of borided samples were obtained three or four times more than that of the matrix structures. The best wear performance was observed for the sample borided at 850°C for 6 h. The mass loss of this boronizing condition is 0,2 mg and this value is nine times less compared with that of the as-cast pearlitic structure.