Abstract

Results of researches are showed, that fabrication technology of sensor elements are used in devices based on surface plasmon resonance significantly affects on the increasing uptime of measuring and substantially increases the sensitivity to low concentrations of analytes. The results of investigations have shown that deposition of plasmonexciting metal layer on glass substrate at the chosen angle enables to enhance sensitivity of the surface plasmon resonance sensor by 1.5 times for liquid media and 2 times for gas-like media as compared with standard gold chips as well as improve uniformity of deposition and durability of ligand binding to the sensitive layer. Diagnostic facilities based on surface plasmon resonance possess a high sensitivity to low concentrations of studied substances, which enables one to use them as precise analytical devices in lab investigations in industry, agriculture, medicine, and ecology.