International Scientific Journals
of Scientific Technical Union of Mechanical Engineering "Industry 4.0"

The current publication presents an approach for the elaboration of a disposable microfluidic hollow micro-channel using 2 photon polymerization technology and Photonic Professional GT2 (Nanoscribe, Germany) equipment. The design of a 3D model of a microchannel is realized by the CAD analysis software – SOLIDWORKS. A suitable laminar flow is generated by using computational fluid dynamics (CFD) software. As a result, the critical points of the pressure, velocity, and wall shear stress into the microfluidic channel are obtained. A real prototype of the hollow microfluidic device is created, using a highly innovative technology of 3D nanoprinting by twophoton polymerization. Experimental studies with dilute erythrocyte suspensions are conducted to test the functionality of the developed prototype of nano 3D printed microchannel.

The present study offers an important technological approach for the development of a disposable microfluidic channel using 3D nanoprinter – Photonic Professional GT2 (Nanoscribe, Germany). This publication aims to present 3D modelling, simulation, and prototype of a 3D nanoprinted microfluidic device for the investigation of blood cells. The design of 3D model of a microchannel is realized by the 3D CAD analysis software – SOLIDWORKS. A suitable laminar flow is generated by using computational fluid dynamics (CFD) software. As a result, the critical points of the pressure, velocity and wall shear stress into the microfluidic channel are obtained. An actual physical prototype of the proposed microfluidic device is developed, using a highly innovative technology of 3D nanoprinting by two-photon polymerization. Experimental studies with dilute erythrocyte suspensions are conducted to test the functionality of the developed real-world prototype of nano 3D printed microchannel.

The cell engineering is one of the most developing fields during the last decade needing specially fabricated polymer microfluidic devices and systems. One of the main functionalities of the microfluidic devices is to mimic the in-vivo environment where the cells and tissue live. The various types in-vitro microfluidic devices and systems could replace the experiments with animals in the biomedical investigations. The aim of this publication is 3D modeling and simulation of a microfluidic device for liver cells investigation. Suitable materials could be used with main properties related with fully transparency and bio-compatibility of the selected polymers. A new technology for development of the microfluidic device will be proposed, incorporating a thin layer of liver cells for investigation of their behavior during treatment with different substances. The conceptual work principle of the developed bio-chip will be presented. The future investigations, related to the fabrication of a real physical prototype and research experiments will be mentioned briefly in conclusions.