International Scientific Journals
of Scientific Technical Union of Mechanical Engineering "Industry 4.0"

Almost half of all known to date proteins contain metal co-factors. Over the course of 3–4 billion years of organism evolution, several metal species of different oxidation state (Na+, K+, Mg2+, Ca2+, Zn2+, Mn2+, Fe2+/3+, Co2+/3+, Ni2+ and Cu+/2+) have been chosen to participate in key biological processes. They are known as “native”, or “biogenic” metals. On the other end stand toxins like mercury and lead, which poison the recipient by competing with the natural co-factors for binding the essential proteins. As a third example, however, should be outlined some abiogenic metal species, which exert a curative effect on the host organism, and are, therefore, applied in medicine as novel drugs. Such are silver (Ag+), strontium (Sr2+), and gallium (Ga3+). The current study investigates their ability to compete with the native cuprous (Cu+), calcium (Ca2+), and ferric (Fe3+) cations, respectively, by exploiting the methods of the computational chemistry. Nowadays, silver finds broad application in many areas of medicinal use, e.g. being added to dressings of burn wounds as a concomitant therapy of skin ulcers, as a potential water disinfectant, or even in ophthalmology as an active component in eye drops. Strontium prevents the destruction of bones and contributes to their restoration. Sr2+ salt of ranelic acid is a medication (under the names Protelos, Protos, Strontium ranelate Aristo) used for treatment of osteoporosis in postmenopausal women and very elderly patients. Gallium, in its cationic form (Ga3+), is well known for its anticancer activity. Nonetheless, recent experimental studies have considered the employment of gallium as a promising “Trojan horse” strategy against pathogenic microorganisms. Herewith, we set on a quest for deciphering the most acclaimed mechanisms of therapeutic action of the aforementioned metal cations at atomic level. The obtained results shed light on the intimate echanisms of metal recognition, thus revealing key factors governing the processes of native/abiogenic metal rivalry. This approach serves not only for explaining already existing experimental findings, but also as a first step in designing/engineering novel drug molecules of potential therapeutic value.

It is presented experiment for temperature measurement in welding process. It is shown arc interference with measurements and temperature versus distance form arc trajectory. This study will help selecting specific points for measuring temperature in welding process..

Thе paper examines the processes associated with the high-energy formation of active elements. A model of the processes is created and certain relations are derived, which are suitable for practical calculations of the parameters of high -energy systems with directional motion. The processes of movement, deformation and penetration of the active element are studied. Methods and means for influencing the processes of creation and improvement of the active elements are proposed.

The paper presents a review of the literature relative to the flue gas desulfurization methods for sulphuric acid (H2SO4) manufacturing. The covered topics include wet and dry methods. Particular attention has been paid to the desulfurization of the flue gas from the copper smelting industry that can lead to a generation of SOx rich streams resulting in high profitability of H2SO4 production.

The Picard’s successive iteration method is applied to determine the Euler critical force for a slender column. The initial approximation of the buckling mode of the column is a polynomial function that satisfies the boundary conditions. A numerical example is solved and the obtained result is compared with that obtained by the Euler formula. An assessment of the accuracy of the solution is made at each iteration step. In the paper is shown that the Picard’s iteration method could also be used for obtaining the closed form exact solution of the buckling load. The investigated column is hinged at its upper end and supported by a Q- apparatus at the other. It is loaded with a compressive force at the upper end.

The rheological non-destructive oscillation testing is conducted in order to predict and quantify the samples’ properties of the commercial brand lipstick. The influence of the variation of the process parameters temperature, phase angle and strain are investigated. Regression models for the dependencies of the rheological and thermal properties (elastic modulus and shear stress) from the described process parameters are estimated, based on 681 experimental data in the temperature region from 26.9 °C to 74.7 °C.

Machine inspection is a mandatory technological process in industrial processing agriculture products. The camera detects color and shape based irregularities of the object resulting in a large number of parameters for decision-making and sorting product compliance. The goal was to discover a new criterion for decision-making using only the output signal of the RGB camera. Research employed the digital images of raspberries, blackberries, peas and yellow beans during real processing, obtained from a color sorter machine. The visual texture of the surface of the agricultural products was described via defined statistical indicators of color (color average value (Avg), standard deviation (Stdv), entropy (E), and lacunarity (L) was used from the sphere of image fractal analysis as one of the criteria. By applying the non-parametric tests: Wilcoxon signed rank and Friedman test, statistically significant difference was established for the L and Е criteria between compliant and non-compliant industrial products.

The cold atmospheric pressure operating plasma /CAPP/ offers attractive opportunities for various surface decontamination treatments of both food products and non-food materials. The technology is especially considered as promising mild but efficient surface treatment of fresh food products in order to extend their shelf live and sustain quality. Here we report evaluation of the effect of CAPP micro torch treatment of Canadian blueberries and cherry tomatoes related with the fruit quality and possible cell wall damages and changes of the total anthocyanins content of treated fruits. The problems and opportunities for further application of plasma jet generated CAPP treatment for fresh fruit decontamination are discussed. Thе research is funded by the Bulgarian National Science Fund under Grant DN08/8-2016.

In recent years, interest in butanol and butyric acid as a potential substitute for traditional fuels has grown. Microbiological production of butanol and butyric acid from carbohydrates is not economically advantageous due to several process defects. The cost reduction potential of the product is related to expanding the substrates used and optimizing the process’ economics. The metabolism of the strains Clostridia is in two stages – acidic and solvatogenic. In the beginning, carboxylic acids are formed, and afterward, these acids induce the preparation of solvents.
The aim of this work is to study the effect of unusual substrate on butyric acid production by Clostridium beijerinckii 4A1. The experiments performed were based on a Reinforced Clostridial medium, using different concentrations of lactic acid as carbon source, at Т= 37 °C, and anaerobic conditions.

Among the various methods for water purification and treatment from contaminated industrial pollutants, one of the most used is the adsorption methods based on activated carbons. The purpose of our study is to investigate the correlation between the porous texture and chemical nature of the surface and sorption capacity of the activated carbon, obtained based on lignite coal. The object of the study is also to determine its effectiveness as a sorbent for Cd-ions purification of contaminated industrial water. The obtained data from the conducted investigation show that the adsorbent based on such kind of activated carbon has good qualities for water purification from various pollutants and heavy metals

This article considers the generation of the canonical form of linear programming to determine the optimal number of techniques. The linear programming problem was solved using the created software interface as a result of solving the problem during the generation process.

The exposure on high concentrations of PM particles causes various serious diseases such as cardiovascular, respiratory related diseases and cancer as discovered in more scientific studies. According to experts, there is no immediate victory for pollution, but action must be taken, as this problem cannot wait for future times and generations. In this paper, we will analyze air pollution with PM10 and PM2.5 in indoor urban areas (apartments, workplaces, etc.). This will help the competent authorities to model an urban development plan, traffic density and air quality measures for the population that spends most of the day in an indoor environment. Another benefit would be to obtain information from the results of the online indoor monitoring – to decide whether purifiers should be purchased to reduce air pollution in permissible limits. Visual modeling with GIS (interpolation) gives a dynamic visual representation of the indoor space, clearly showing which parts of the place are polluted and accordingly take action.